The action-packed event takes place at the University of Bolton Stadium on Saturday 17 April, and will be broadcast live on IFL TV.
Edmondson (4-0, 1 KO) is making his return to the ring following an extremely impressive showing in his last fight, as he picked up a third round stoppage win over John Telford in December.
He now faces another step up against Blackledge (26-9-2, 9 KOs), who won the Commonwealth title back in 2015 and made two successful defences of the belt. Blackledge has also shared the ring with the likes of Callum Smith and Rocky Fielding during his career.
The planned fight between John Joe Nevin and Shaun Cooper for next week’s #MTKFightNight event has unfortunately been postponed after Nevin tested positive for COVID.
MTK Global Promoter Lee Eaton said: “This is a brilliant test for Lewie Edmondson in just his fifth professional fight. Luke Blackledge has mixed it with some of the best in the division, so it’s a great opportunity to see where Lewie stacks up against them.”
Elsewhere on the card, Danny Dignum defends his WBO European middleweight title against Andrey Sirotkin, Dan Azeez puts his English light-heavyweight belt on the line against Ricky Summers, Joe Ham collides with Jack Bateson, Paul Ryan makes his professional debut against Kyle Hughes, Fearghus Quinn is back in action, Paul McCullagh meets Anthony Woolery, and Carl Fail returns.